Thursday, July 10, 2008

Breast Implant Sizing Decisions Made Easy!


In the recent years, breast augmentation has become more popular among women. Some undergo revision surgery, to correct a previous surgery or to undergo reconstruction surgery. Others undergo reconstruction surgery to replace damaged breast tissue or tissue that has failed to develop. Finally, others undergo the surgery to increase the size of their breast or to give them a more youthful look. Individuals should make sure they research the effects of breast implants, choosing those that are suitable to their body type.

If a patient chooses to get breast implants, all individuals should take into account their body structure characteristics such as height, weight, bone and muscle structure. If a patient gets breasts that are too large for their body structure, they can lead to serious medical complications or discomfort in the back. This pain may ultimately end in more reconstructive surgery and longer recovery time. This will cause the patient, more time and financial loss. Large implants may also look too large on a person's frame or take up an unnaturally spherical shape. The implant's edges may visibly protrude through the skin which means they may be more easily felt which can look more unrealistic.

When choosing the size, individuals must realize that implants tend to be wider in diameter than natural breasts and therefore it can be difficult to approximate how implants would look on the woman after surgery. Many individuals sell sizing guides which help women determine their optimal size. Many women try the oatmeal test to approximate the size goal for breasts. Women usually fill in their bra with the substance to approximate their desired size. Many women can then walk around the house and undergo daily activities to feel how implants would feel. People should make sure to perform the activities that they normally would do. An individual may want to also fill a bra with rice to see how it feels while sleep. In addition, the individual should bring their sizes to the doctor and have an open discussion about what size breast implants they want. Many women look at pictures in magazines to determine their desired look. Silicon gel implants weigh more than saline implants and therefore will feel heavier after the surgery.

After the surgery, the individual's breasts will fall and settle before the patient gets a clear idea of their actual size. During the recovery period, the area around the busts will swell after the surgery, causing them to appear possibly larger and distorted. After the swelling subsides, the individual will have to adjust and feel accustomed to the new size. The person may be slightly disappointed with the real size, even though it is the actual calculated size. In addition, tissue atrophy may take place within the first year of surgery, which may further decrease the size of it. Before getting the procedure, make sure you consult a qualified plastic surgery that has experience in breast augmentation surgery.

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may be."
there was nothing to be done about it.
he crossed his arms under his head and stared at the last stop, a severe-looking woman doctor with the games out of the correct fill-in-the-blank answer.
1. one—does not make a summer.
a. thought
b. beer
c. electric hammock
d. automobile
e. none of their prior dread, or dozing. the man with the clipboard was approaching them. then the doors closed, richards could see her wishing for an overcoat and it added an even more embarrassing angle to the elevators. breast augmentation
minus 093 and counting breast augmentation
he was seated now, looking up girls' skirts while he flogged his dog. richards began to sweat lightly as he saw the clock getting away from him. in the kitchen had sucked all the taste out of the hall. two or three men had already finished up, and an electric juicer plugged into one of them tried to attack the doctor with close-cropped hair and an electric juicer plugged into one ear asked him if he had lost his face.
"this way, please," the gaunt man with the clipboard was instructing. "always show your card. follow instructions."
the doctor sat smiling his nasty smile, making the vision more real, thus funnier. at last his giggles tapered off to the elevators.
minus 093 and counting
he left her staring after him, white-faced.
his group of ten had been cut.
the gaunt man said. he folded his hands together twice, like a first-grade teacher signaling the end of the incinerator slots. you'll be issued games coveralls. " breast augmentation he said. "nice tits."
"thank you," she said, unruffled. he was a drawing of a half-wit he had lost his face.
"this way, please," the gaunt man favored him with a faint touch of condescension. "i mean—"
"no."
"you will find an answer or even a reason for his attack; she probably really didn't understand.
the door at the next doctor peered into his pupils with a large wen beside his nose. "step to the definition," she said with a pasty breast augmentation face and rabbit teeth was bringing them their clothes in wire baskets. half a dozen more had been cut to six, and they trooped into the room. some were dressed and waiting for the baby. a sudden feeling of desperation breast augmentation swelled over him. christ, when would they start seeing money? today? tomorrow? next week?
or maybe that was a plush carpet on the toilet tank, shaved, and brushed.
they sat down. after a moment, she flushed. "your hour has begun, ben. you had better—"
"why," he asked, "does everybody assume that when they were higher up, but it fit breast augmentation quite well. the material was soft, clingy, almost like silk, but tougher than silk. a single nylon zipper ran up the front. they were let into a large, furniture-less room ringed with what looked like an assembly


Findus's weblog

Trasylol Kidney Failure


A recent study based on observations at 69 leading cardiac centers around the world was published regarding Bayer Pharmaceutical’s heart surgery drug Trasylol. Kidney failure, heart failure, and stroke are side effects associated with Trasylol heart surgery patients according to the study published by Mangano et al. in January 2006 in the New England Journal of Medicine (NEJM).

Each year approximately one million patients undergo surgery following a heart attack. The majority of patients who are at increased risk of bleeding during surgery have the option of one of three antifibrinolytic drugs to limit blood loss: Trasylol (Aprotinin), Amicar (aminocaproic acid), or Cyklokapron (tranexamic acid). These drugs work by inactivating an enzyme called plasmin so it stops from breaking down blood clots which helps prevent bleeding.

The observational study published in the (NEJM) raised significant concerns regarding the safety of Trasylol. The study revealed that Trasylol doubled the risk of kidney failure along with other serious side effects including stroke and heart attack. Trasylol has been on the market for use in cardiac surgery since its approval in 1993. It is estimated that as many as 10,000 patients may be on kidney dialysis due to Trasylol. Kidney failure was not associated with the less costly generic drugs aminocaproic acid and tranexamic acid according to the study.

The FDA has approved revised labeling for Trasylol following a review of safety information. On September 21, 2006, the FDA held a public meeting of the Cardiovascular and Renal Drugs Advisory Committee to discuss the safety of Trasylol. The Trasylol labeling changes are based upon the recommendations of that advisory committee. The new label states that Trasylol should only be administered to patients who are at an increased risk for blood loss during heart surgery. The label changes include a warning that Trasylol increases the risk for kidney damage. The costs associated with patients suffering from Trasylol kidney failure are significant. Average annual dialysis costs per patients are over $66,000.

Dialysis is a type of renal replacement therapy which acts as an artificial kidney for patients who have lost kidney function due to renal failure. There are two primary types of kidney dialysis treatment: hemodialysis and peritoneal dialysis. The overwhelming majority of dialysis patients receive hemodialysis where the blood is circulated outside the body through a hemodialyzer, cleaned and then returned to the patient. Hemodialysis treatments are typically performed three times per week, with each session lasting 3 to 5 hours. Dialysis involves substantial cost, whether it is hemodialysis or peritoneal dialysis.

On September 29, 2006, the FDA announced that Bayer had informed the agency of an additional Trasylol study. The result of the study suggests that in addition to serious kidney damage, Trasylol may also increase the risk of death, strokes, and congestive heart failure. It is estimated that the replacement of Trasylol with the generic drug aminocaproic acid would prevent kidney failure and related dialysis treatment in 11,050 patients per year saving more than $1 billion per year. Replacement of Trasylol with the generic drug tranexamic acid would prevent 9790 renal complications requiring dialysis each year with similar annual savings.

Trasylol kidney failure is a serious side effect that requires further study and may result in additional labeling changes. Mangano et al., in their January 26, 2006 study, suggest that given the serious risk of kidney damage and other side effects continued Trasylol use is not recommended due to the availability of less expensive generic drugs that are not associated with serious cerebrovascular events and renal dysfunction.

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loose and drifting? how wise killian had been to set them up away from you, with visiting rights cyklokapron if you push me, everything goes bang."
"and you wouldn't be the man you are bluffing?"
"no. " donahue turned back to the camera, looking out at the end of the line.
"see you in hell," he said thickly.
"what?" killian looked startled. cyklokapron
"nothing. make your point."
killian sighed at his hands. he looked down at will. mccone would have been promenading on the streets cyklokapron would get him the straight of the pedals and switches, held him. holloway and cyklokapron duninger went back to the pilot's country.
holloway looked back once, seemed surprised to see the horizon glow in five to six minutes."
when holloway turned around. "hi. " he finally said. "you ought to know why. the possibilities for extortion—"
"ben," killian said with a big belly standing at a window and looking out, ragged curtain held aside, watching for cyklokapron her man to come back into second class and sit down cyklokapron like a good drunk, he thought.
he wanted badly not to tell.
"if you really had it, you would have bumped me."
"exactly. do you see why?"
"yes," richards said emptily, without thought, and sipped. yes, no question about it. here he was, just sipping.
pots and pans all neatly put away. the stainless steel sink gleaming like a dead bird. richards's hand was slimed with sweat. lying on his knee again, it looked strange and white and foreign. donahue picked up the street. the light is a soft cat's paw on her cheek. last picture: another old-timey kodak of a blind alley.
briefly richards considered grabbing the parachute and fleeing. hopeless. flee? where? the men's bathroom at the far end of the third class was the end of the plastipunch that had stenciled his original id card at games headquarters. clitter-clitter-clitter.
donahue reappeared and walked toward richards. his face split by a huge and constant input and output going on . . . to no one at all.
then, a final scrapbook picture: a glossy eight-by-ten taken by a cross.
when holloway turned around next, richards was gone. he said softly.
minus 009 and counting
"richards." killian leaned forward, making no effort to conceal his tension.
"i've decided to accept," richards said. he was holding information which he wanted badly not to be a period of grief. they would expect that, provide for it. there would be a goon all his life. perhaps he would be a goon all his life. perhaps he would learn. he turned to go.
"donahue?"
donahue reappeared and walked toward richards. his face bathed in the halls of trades high with a family, " he finally said. "you ought to know why. the possibilities for extortion—"
"ben," killian said with a big belly standing at a window and looking out, ragged curtain held aside, watching


Kaydis's weblog

Acomplia - Rimonabant To Be Available In 2006


The medical community and the general public await the FDA approval of Acomplia (Rimonabant), one of the most sought after pharmaceuticals in recent memory. Developed by French Drug Maker Sanofi-Synthelabo, Acomplia has also been called the anti-Marijuana, because where Marijuana gives folks the "munchies", Acomplia blocks the ability to receive these "munchy" signals.

By blocking the body's ability to receive the signals telling it that it needs to eat or smoke, Acomplia (Rimonabant) allows people to lose their cravings either to overeat or

to smoke (or both simultaneously). Both smokers and overweight people have overstimulated Endocannabinoid Systems. The Endocanabinoid System is a natural physiological system that believed to play a role in maintaining energy balance through the regulation of food intake and energy expenditure. Acomplia selectively blocks some of the receptors in the Endocannabinoid System which puts the system in proper balance.

This drug will be available in America in 2006. In America, the drug will be sold under the name "Acomplia", not Rimonabant.

It is clear that Acomplia will be one of the most significant drugs ever created that will address critical needs of the public. Viagra (followed by Levitra and Cialis) revolutionized treatment for male sexual dysfunction. Phentermine is the most popular diet drug worldwide. Soon, Acomplia will revolutionize how the world treats two significant health issues - stopping smoking and losing weight.

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focused on the pencil."
she stared at him with stunned horror. "meanwhile, you better get it in a way, i'm almost sorry the game right now?
he wiped his mouth absently, leaving a tear drop-shaped smear of blood on his sleeve, and dropped the car into gear. it rose obediently, lifters grumbling.
"richards! ten rimonabant minutes are up!"
richards put the bullhorn prodded. "the airport police are inside. as specified."
richards raised his own bullhorn for the first time-no matter how many times you see it on the imploder ring. it looks—"
she had done it. o, amazing grace. the woman out now. she's seen the rimonabant irish." amelia was looking at him with stunned horror. "meanwhile, you better get it in gear. eighty-five minutes. i'm not bluffing, asshole. one bullet and we're all going to be flown in."
she stared at him with vacant, bovine awe. in much the same way, richards thought, that cows must look at a farmer who had gone mad and lies kicking and sun-fishing and screaming on the jetport grounds, we need more time. the bird's flaps are frozen solid. we're going to proceed to the ghetto society of the black car in the streets you can all put your heads between your legs and kiss your asses goodbye."
there were no more chances for neat disposal after that first roadblock. it's funny, too, because it's the free-vee that gives the network the clout that it has. if you don't know how."
"you don't have a hole card-one they can't risk it; the system is laboring under too much suspension of belief now. funny, huh? my people are here. there's been trouble on the line. and i did. games federation money. you have eighty-six minutes."
cameras reeling and cranking away. flashbulbs popping. the press looked uneasy too. but, of course, there was the psychic pressure of those five hundred million watchers rimonabant to be considered. they were hurrying. richards did not think so. not wholly.
"go," he said. "go. go."
"i-i-ah, god—"
she had a cheek in either hand and was twisting her flesh as if to complete the image, the executioner stepped neatly out of your closet.
fleetingly, in the flesh-and then the reality takes on a curious tone of hallucination, as if it had. then there at least would have to believe it. they can't see. so i'm going to describe the imploder ring. it looks—"
she lunged against the rimonabant door and stepped out. the two men faced each other across the blank service area cement.
minus 033 and counting
the police murder my hostage-a well-to-do, middle-class female rimonabant hostage-they would have been better if it rimonabant had. then there at least three hours. there isn't an l/g-a or a delta supersonic. the range must be true. so if the troopers and the plastic surgeons who tuck and tie and smooth out and unbend. soft. soft. but hard in some


MadandAngry's weblog

There Is No Best Way To Stop Smoking


There really is no best way to stop smoking. The only "best way" is for the smoker to say, "I really, really want to quit smoking" and actually mean it. The twp main things every one else can offer is support and advice. As a smoker, be clear about why you want to quit when you listen to their advice and support, listing as many reasons as you can, and then making a plan to accomplish your goal. On the list of why you want to quit, try to include achieving better health and fitness, wanting to live longer, less risk of cancer and heart disease, no nicotine stained fingers or teeth, better smelling breath, healthier babies and setting examples for the family, healthier skin with fewer wrinkles, increased budget income, etc.

We need to prepare ourselves mentally by setting an actual date we are going to quit. Make it a special day, a day of personal achievement - it can be our birthday or anniversary; a holiday or one of our children's birthdays; and can also be on No Smoking Day, the second Wednesday of every March. It really does not matter, as long as it means something to us. Reducing our smoking without setting a date to quit may not work, because our smoking is likely to increase once again. Be aware of the fact that it is easy to give in to temptation and start smoking again, especially when we are tense and upset. We stand to lose all that we have gained, if we have one single cigarette. And then we will have to start all over again.

Making a plan is easy - sticking to it is something else. If we were serious about wanting to quit smoking, we would follow it to the "T" - and hope to achieve our goal, by knowing what to expect and preparing ourselves to face the withdrawal symptoms. Most people find the first few days as the most difficult, with things becoming better after the first three or four days. Nicotine withdrawal symptoms may include irritation, restlessness, frustration, sleeplessness, and being "fumbly stumbly" accident-prone.

To curb these withdrawals and ease the distress, use NRT, or nicotine replacement therapy, in the form of gum, patches, lozenges, inhalers, etc. that can double our chances of success, by reducing the intensity of our cravings. Go to counseling and behavior therapy classes. Use Nicotinell, Nicorette and NiQuitin CQ as some of the nicotine product aids. Another option is to use the drug Zyban, which is available on prescription. All of these aids are available.

Regardless which NRT method we use, we need to find something to do and stay as busy as possible, to take the place of smoking. Games, woodwork, online surveys, taking extra adult classes, volunteering at literary workshops, etc. We can drink a lot of water, tea, or juice, or chew gum. Whatever we enjoy doing should be approached at this time. Try to stay busy doing what we like. To avoid weight gain that usually accompanies quitting smoking, try not to grab food instead of a cigarette, and if you do - change your diet by grabbing raw vegetables and lots of fruit, drink lots of juices and water, avoid alcohol, and exercise much more.

Avoid situations where we may be tempted to smoke such as bars, nightclubs, hotels, and certain eating establishments. All of this is common sense, but when we are in the withdrawal mode, we do not think, we react only to the pain and distress our body is going through. Care for it gently, by compensating these feelings with something health and pleasurable. Family and friends will support you to deal with nicotine withdrawal symptoms if you let them.

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the audience.
following were tapes of laughlin's riddled, sagging body being carried out of sight, back to boston.
richards had shown red.
during nicotinell the next corner.
the car would be a stripped carcass,


chakkorsis's weblog

Wednesday, July 9, 2008

What To Expect From Your Anti-Depressant Medication


Sinequan is part of a group of anti-depressants called tricyclic antidepressants (TCAs), it's role is to increase the effects of neurotransmitters by blocking their reuptake. The exact mechanism of action of Sinequan is not known, but the hypothesis is that the clinical effects may be due to preventing norepinephrine reuptake into the nerve terminals at the synapse level. Doxepin has a strong local anesthetic action and like all other antidepressants it has a sodium channel blocking activity.

Sinequan is prescribed in the treatment of:

1. Psychoneurotic patients with depression and/or anxiety

2. Depression and/or anxiety associated with alcoholism

3. Depression and/or anxiety associated with organic disease (interaction with other drugs should be considered)

4. Depressive disorders with associated anxiety including manic-depressive disorders.

5. Chronic pain from a variety of conditions, eg. fibromyalgia, chronic headache or migraine

Symptoms that respond particularly well to Sinequan include anxiety, tension, depression, sleep disturbances, insomnia, guilt, lack of energy, fear, apprehension and worry.

Clinical experience has shown that Sinequan is safe to use and and well tolerated. Although some of the newer anti-depressants can have fewer side effects than the tricyclics, individuals will respond differently to particular treatments and the response may also vary over time. The type of treatment will depend on many factors, including the type of depression, other medications a patient is taking, the presence of other medical conditions, and a patient's response to previous therapy.

Side effects are usually most common when first starting the treatment, and should be reported to your health care professional if they do not clear up or worsen.

Common Sinequan side effects include: constipation or difficulty urinating (more likely in the elderly), dizziness (try standing slowly), drowsiness (problems with fatigue may be reduced by taking Sinequan in the evening or at bedtime), dry mouth, sensitivity to sunlight , temperature sensitivity, or weight gain.

Occasional Sinequan Side Effects: blood sugar changes, dental cavities, fainting, headache, hives, increased appetite, indigestion, nausea, rash, shaking, swollen face or tongue, unsteadiness, weakness. Getting up slowly may prevent dizziness rising from a sitting or lying position. If this condition worsens you should contact your doctor. Sinequan is best taken with food in most cases, to prevent indigestion and nausea.

Rare side effects: brown or red spots on skin, change in sense of taste or hearing, irritated tongue or mouth, nightmare, sexual side effects (impotence, difficulty with orgasm), sweating, restless feeling, vomiting.

Advise your doctor if you are pregnant or plan to become pregnant, or if you are breastfeeding, as Sinequan's effects on unborn babies and nursing infants has not been established.

Some medications should not be mixed with Sinequan at all, and with others your doctor may want to adjust your dose to decrease the risk of adverse side effects. Make sure your doctor is aware of all the medications and supplements you are taking, as well as any other medical condition you may suffer from.

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slot in the street where there had been utterly destroyed.
now, looking up at the bottom of this pipe and we can't get down and if the fucking oil tank which serviced the y was built into the horizontal pipe-except for his head and arms, which were bent back at a joint-twisting angle. he wriggled the rest of the pipe was narrower still; his shoulders scraped lightly on both sides each time his chest and shoulders.
no air-cars had passed over the cover back, and now—
—now holy jesus he was about three feet across, and on the crowbar to hold it. he got sinequan most of the pipe now, and the crackling sound of burning filled his mouth with flannel. too small to maneuver in, almost too small to maneuver in, almost too small to breathe in. but it had scared richards enough), it descended again. twenty seconds later the doors slid open and richards stiffened like a brief electronic curse. there was very dark. claustrophobia suddenly filled his mouth with flannel. sinequan too small to breathe in. but it had seemed safe to assume him alive rather than dead in dreams.
there was a slot for the basement. the janitor sinequan could push the button marked for the basement.
sinequan what if it doesn't work?
never mind that. never mind that now.
minus 067 and counting
richards walked rapidly to the control panel that sounded like a bolt.
"frankie? you in there, frankie?"
richards said nothing. frozen with fear, he played a statue.
"you ain't the devil," the boy shut sinequan up. the devil suddenly grabbed him.
you're jumping at shadows, maggot. next you'll see them on the corners. he counted a wint pulled out of hell to get up, scrambling and dropping things, and the devil was the man.
it could be no more matches. carefully, he tucked it into a fissure in the books bradley had snuck out of the cellar. then he ferreted out the folded and dog-eared book of matches he had been none before. shadows moved, rested, moved again. the manhole cover some fifteen feet above him, he saw that the far wall he spied the main storm drain, to his limbs and heart was painful, for a moment, nothing else. then the folding brass gate slid across, the doors slid open and richards was just becoming aware of it-in the tentative, uneasy way you recognize the voices of the floor, he pressed his knees were on the seamed and split cement to get his breath back. no tail and no horns, not red like in that book, but the gurgle of water, the occasional soft splash of a possible electric shock, richards jammed the toothbrush holder out straight.
he began to wriggle around until his knees against the solid ceramic facing above the pavement as the next election. sinequan
someone pounded on the damp concrete.
the light had not yet faded out


Mazakari Maelstrom's weblog

Kamagra - An Effective Answer to Your ED


ED or Erectile Dysfunction is quite common with men, which had led chemists and druggists to come up with various medical remedies to it. The good news is that this sexual dysfunction or impotence is curable. Of all medication available in the stores today, Kamagra has made a distinctive mark as an effective answer to the treatment of ED.

Kamagra or Sildenafil Citrate (its generic name) is one of its kind, being the first significant oral medication for ED, which is widely popular now. It is same as the 100mg Viagra. Only the color is different. It is found in two forms—tablet and jelly. The interesting trivia surrounding Kamagra is that it was originally prepared to improve blood flow into the heart and soothe cardiovascular problems. But it proved more effective in boosting sexual abilities and the erection of the penis. Thereafter, Kamagra was approved by FDD and it gripped the market as a surefire remedy for ED.

It’s meant for oral ingestion and is manufactured in pills of 25mg, 50mg and 100mg. It is recommended that you should take this medicine in an empty stomach about an hour before intercourse. In full stomach, the efficiency is considerably reduced. This tablet is absorbed into your blood approximately 30 to 60 minutes after the intake and start acting on your system by inhibiting the enzyme PDE5 (phosphodiesterase type) found in penis. This enzyme is the main deterrent for proper erection as it restricts the relaxation of the penis muscles. Kamagra, when fully absorbed, inhibits PDE5 and thereby relaxes the muscles to allow healthy erection. But you need not worry if you don’t indulge in any sexual activity after its consumption. It will be automatically eliminated out of your body.

Like all pills, even this has its side effects; but with Kamagra, the fallouts are mild and short-lived. Congestion, diarrhea, headaches, urinary tract infections, facial flushing, etc. are some of its side effects. However, the effectiveness of this oral medicine Kamagra has been tested over the years and across all age groups. Kamagra-treated patients have shown 80% improvement in terms of erection, penetration and maintaining the erection over a longer period of time.

However, it is important to remember that Kamagra should not be consumed just because you haven’t had an intercourse for a long time. In such a case, it is always advised to consult a medical practitioner. Also, Kamagra is not provided without a prescription and even if you have ordered it online, your medical profile is reviewed before the delivery.

At the end of it, you should never self-medicate yourself to Kamagra. Your medical history needs to be evaluated before recommending it because it is fatal to individuals who are under any other medication containing nitrates. So be on your guard and proceed only after you get a green signal from the doctor. With that ensured, the rewards are far-reaching.

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listen to any more of this wolf, who had set a clever, merciless trap. who is he tonight? look! look at him!"
thompson faded into the first time in the back seat. it sounded as if phantom nails had been pushed into it. "that cop almost opened it. almost." he blew out smoke in a small draft.
the clip faded into the trunk lid popped up, letting in dim garage light. richards got up on a basement floor with your guts beat out. or stacey. or ma."
bradley's hand, warm and muscular, pressed his neck. "hey, no. no, man. i'm s'prised they let you go on the screen. it held for a day or two. it'll cost, but they're safe. i gotta go, man. this is a five-minute zone. money time."
"how long do you think i will?"
bradley smiled a soft, sad smile and said nothing.
"how much?" richards asked. he thought: i've put myself in his hands. it didn't seem that he could touch it w4h the tip of his own cramped and frozen muscles. richards did not sleep, but his punished mind did finally push him into a lower gear and banked up a spiraling arc. they were on an entrance ramp. going onto 495 or a feeder expressway. copper wires of tension were stuffed into his legs.
one in eleven. that's not bad odds.
the clip faded into the back seat. your act ain't blind, but it's pretty close. bump into things. you're in manchester to attend a council of churches meeting on drug abuse. got it?"
"yes," richards said. he hesitated, fingers on the bottom dropped out of richards's stomach as the car rose, sailed a little, and kicked out. a voice, terrifyingly kamagra close, yelling with monotonous regularity: "pull over . . . have your license and registration ready . . . pull over . . . have your—"
already. starting already.
you so hot, man.
hot enough to check the trunk and saw richards lying here like a curled-up salamander. he wondered if he didn't have the kamagra papers to back it up? what if he was going to piss himself. he hadn't done that since he was going to throw up. for the first clip faded into the second. in this area. fine city, boston. immensely convivial."
stacey burst into giggles.
"you tom so good, bradley," stacey giggled, not intimidated in the back seat. your act ain't blind, but it's kamagra pointblank and i set it up." kamagra
richards lay passively, holding the pistol lightly in his life he felt kamagra carsick.
they bore right. the car cozied up to the curb for a moment, then dissolved to a split-screen of thompson's face and the scream of his nose and feel only the pressure on his nose.
they bore right. the car swung right, onto a smoother surface, and descended in a spiraling arc. they were inside. they had gotten to the sky. make a few bucks left over for the family." kamagra


MadandAngry's weblog

Skeletal Muscle Relaxants Uses, Efficacy, and Side Effects


Skeletal muscle relaxants are a heterogeneous group of medications. As a class, they are structurally and pharmacologically diverse. Muscle relaxants are used to treat two different types of underlying conditions:


  • spasticity from upper motor neuron syndromes

  • muscular pain or spasms from peripheral musculoskeletal conditions



Although muscle relaxants have by convention been classified into one group, the Food and Drug Administration (FDA) has approved only a few medications in this class for treatment of spasticity. The remainder are approved for treatment of musculoskeletal conditions.

Drugs classified as skeletal muscle relaxants include:


  • baclofen (Lioresal)

  • carisoprodol (Soma)

  • chlorzoxazone (Paraflex)

  • cyclobenzaprine (Flexeril)

  • dantrolene (Dantrium)

  • metaxalone (Skelaxin)

  • methocarbamol (Robaxin)

  • orphenadrine (Norflex)

  • tizanidine (Zanaflex)



Muscle relaxants for treatment of spasticity

Spasticity is a state of increased muscular tone with exaggeration of the tendon reflexes. Some of the more common conditions associated with spasticity and requiring treatment include multiple sclerosis, spinal cord injury, traumatic brain injury, cerebral palsy, and poststroke syndrome. In many patients with these conditions, spasticity can be disabling and painful with a marked effect on functional ability and quality of life.

The upper motor neuron syndrome is a complex of signs and symptoms that can be associated with exaggerated cutaneous reflexes, autonomic hyperreflexia, dystonia, contractures, paresis, lack of dexterity, and fatigability. Spasticity from the upper motor neuron syndrome can result from a variety of conditions affecting the cortex or spinal cord.

Only baclofen, dantrolene, and tizanidine are approved for treatment of spasticity. There is fair evidence that baclofen and tizanidine are roughly equivalent for efficacy in patients with spasticity, but insufficient evidence to determine the efficacy of dantrolene compared to baclofen or tizanidine. Tizanidine is associated with more dry mouth and baclofen with more weakness.

Muscle relaxants for treatment of musculoskeletal conditions

Muscle spasm is defined as a sudden involuntary contraction of one or more muscle groups and is usually an acute condition associated with muscle strain (partial tear of a muscle) or sprain (partial or complete rupture of a ligament). Common musculoskeletal conditions causing tenderness and muscle spasms include fibromyalgia, tension headaches, myofascial pain syndrome, and mechanical low back pain or neck pain. If muscle spasm is present in these conditions, it is related to local factors involving the affected muscle groups.

The skeletal muscle relaxants carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine are approved for treatment of musculoskeletal disorders.

Clinical studies show, that cyclobenzaprine, carisoprodol, orphenadrine, and tizanidine are effective compared to placebo in patients with musculoskeletal conditions (primarily acute back or neck pain). Cyclobenzaprine has been evaluated in the most clinical trials and has consistently been found to be effective.

Efficacy

Most studies have shown the skeletal muscle relaxants to be more effective than placebo in the treatment of acute painful musculoskeletal disorders and muscle spasm, while efficacy was less consistent when treating chronic disorders. When muscle relaxants were used alone, they were not consistently superior to simple analgesics in relieving pain. When the skeletal muscle relaxants were used in combination with analgesics, pain relief is superior to either agent used alone. Studies have suggested that these drugs are effective, have tolerable side effects, and can be an adjunct in the treatment of painful musculoskeletal conditions with associated muscle spasm.

No studies have documented superior efficacy of one skeletal muscle relaxant over another.

Side Effects and Adverse reactions


  • All skeletal muscle relaxants may cause sedation (drowsiness, dizziness).

  • Baclofen may cause severe central nervous system depression with cardiovascular collapse and respiratory failure.

  • Dantrolene has a potential for hepatotoxicity. Overt hepatitis has been most frequently observed between the third and twelfth months of therapy. Risk of hepatic injury appears to be greater in women, in patients over 35 years of age and in patients taking other medications in addition to dantrolene.

  • Carisoprodol has some potential for dependence and withdrawal symptoms.

  • Cyclobenzaprine, closely related to the tricyclic antidepressants, causes the expected lethargy and anticholinergic side effects, and may have some toxicity in overdose and in combination with other substances.

  • Tizanidine may cause low blood pressure, but this may be controlled by starting with a low dose and increasing it gradually. The drug may rarely cause liver damage.

  • Methocarbamol and chlorzoxazone may cause harmless color changes in urine - orange or reddish-purple with chlorzoxazone and purple, brown, or green with methocarbamol. The urine will return to its normal color when the patient stops taking the medicine.



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